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SUMMARY OF RESULTS OF CONTROLLED STUDIES USING ALKALINE WATER

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Title:
Degradation of myocardiac myosin and creatine kinase in rats given alkaline ionized water.
Author:
Watanabe T; Kishikawa Y
Address:
Department of Veterinary Physiological Chemistry, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
Source:
J Vet Med Sci, 1998 Feb, 60:2, 245-50
Abstract:
Recently, the authors have shown that marked necrosis and fibrosis of myocardium were observed in rats given alkaline ionized water (AKW). To clarify the cause of myocardial lesions, the activities of myosin ATPase, actomyosin ATPase and creatine kinase (CK) in myocardium of rats given AKW at 15 weeks-old were compared with those in myocardium of rats given tap water (TPW). Furthermore, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of myocardiac myosin and isoelectric focusing (IEF) of myocardiac CK were performed which revealed a distinct difference between AKW and TPW groups. The activities of myosin ATPase and actomyosin ATPase in the AKW group were higher than those in the TPW group, and these elevated activities were caused by the degradation of myosin in the AKW group judging from the SDS-PAGE pattern of myosin. On the other hand, the activity of CK in the AKW group was lower than that in the TPW group, and the IEF pattern of CK showed leakage of myocardiac CK. These results indicate that increases in actomyosin ATPase activity and myosin ATPase activity, plus the decrease in CK activity caused the disorder of coupled reaction in male rats given AKW at 15 weeks-old. It is concluded that this disorder of coupled reaction may cause marked myocardiac necrosis and fibrosis in rats given AKW.
Language of Publication
English
Unique Identifier
98185639




Title
Influence of alkaline ionized water on rat erythrocyte hexokinase activity and myocardium.
Author
Watanabe T; Kishikawa Y; Shirai W
Address
Department of Veterinary Physiological Chemistry, College of Bioresource Science, Nihon University, Kanagawa, Japan.
Source
J Toxicol Sci, 1997 May, 22:2, 141-52
Abstract
Alkaline ionized water (AKW) produced by the electrolysis of tap water (TPW) was given to pregnant rats throughout gestation. AKW was subsequently given to infants as a test group until 15 weeks old to determine changes in body and organ weights, erythrocyte hexokinase (HK) activity and histological preparations of myocardiac muscle. The results were compared with those for rats given TPW. Body weight of male and female rats given AKWA at 3 to 11 weeks of age after birth significantly increased beyond control group values. Organ weights of offspring at 15 weeks-old showed no statistical difference for either group. HK activity, the rate-determining enzyme in erythrocyte glycolysis, significantly increased in males given AKW at 15 weeks-old. This suggests that AKW intake causes elevation of metabolic activity. Hyperkalemia was observed in males and females given AKW at 15 weeks-old. Especially in males, pathological changes of necrosis in myocardiac muscle were observed.
Language of Publication
English
Unique Identifier
97341750




Title
Histopathological influence of alkaline ionized water on myocardial muscle of mother rats.
Author:
Watanabe T; Shirai W; Pan I; Fukuda Y; Murasugi E; Sato T; Kamata H; Uwatoko K
Address:
Department of Veterinary Physiological Chemistry, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
Source:
J Toxicol Sci, 1998 Dec, 23:5, 411-7
Abstract:
We have reported that a marked necrosis and subsequent fibrosis of myocardium occurred among male rats 15 weeks old given alkaline ionized water (AKW) during gestation and suckling periods, and after weaning. In this study, it was examined whether similar lesions would occur in mother rats which were given AKW from day zero of gestation to day 20 of lactation. The myocardial lesion in the mother rats given AKW showed cell infiltration, vacuolation and fibrosis in the papillary muscle of the left ventricle, as were observed in male rats of 15 weeks old. Myocardial degeneration may cause a leakage of potassium into the blood that results in a higher concentration of potassium in the blood in the test group than in that of the control group given tap water.
Language of Publication
English
Unique Identifier
99121699










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